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Journal of magnesium
and alloys

Current Issue

Corrosion in Mg-alloy biomedical implants- the strategies to reduce the impact of the corrosion inflammatory reaction and microbial activity

Available online 09 January 2023

Full Length Article

Soumya Saha, Widya Lestari, Caroline Dini, Murni Nazira Sarian, Hendra Hermawan, Valentim A.R. Barão, Cortino Sukotjo, Christos Takoudis


The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri‑implant infection (or implant-related infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri‑implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.


Mg-alloy implants review; Corrosion and inflammation; Microbial infection

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