Available online 09 January 2023
Abstract
The most common complication of orthopedic surgery is implant failure,
which can result in catastrophic injury and a significant financial
burden for patients. Implant failure can be caused by a variety of
factors, the most common of which are peri‑implant infection (or
implant-related infection), excessive inflammatory response which caused
pain and aseptic loosening. Orthopedic surgeons now have a variety of
options for treating these issues, including revision surgery, which has
demonstrated to be effective. If excessive inflammatory reaction caused
by the corrosion and peri‑implant infection can be avoided, it will be
of enormous social benefits. This review will provide a summary of
corrosion and the inflammation reactions due to the corrosion and
antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive
inflammatory response and enhancing the antimicrobial activity are
discussed in this review.
Keywords