Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium
Available online 12 October 2023
Full Length Article
JianLiang Zhao, HanRui Cui, ZeYu Gao, YanZe Bi, ZhenZhen Dong, Yan Li, CaiQi Wang
magnesium is an ideal material for hard tissue repair and replacement.
However, its rapid degradation and infection after implantation
significantly hindersclinical applications. To overcome these two
critical drawbacks, we describe an integrated strategybased on the
changes in pH and Mg2+ triggered by
magnesiumdegradation. This system can simultaneously offer anticorrosion
and antibacterial activity. First, nanoengineered peptide-grafted hyperbranched polymers (NPGHPs) with excellent antibacterial activity were introduced to sodium alginate (SA) to construct a sensitive NPGHPs/SA hydrogel. The swelling degree,
responsiveness, and antibacterial activity were then
investigated,indicating that the system can perform dual stimulation of
pH and Mg2+ with controllable
antimicrobial properties. Furthermore, an intelligent platform was
constructed by coating hydrogels on magnesium with polydopamine as the
transition layer. The alkaline environment generated by the corrosion of
magnesium reduces the swelling degree of the coatingso that the liquid
is unfavorable for contacting the substrate, thus exhibiting superior corrosion resistance.
Antibacterial testing shows that the material can effectively fight
against bacteria, while hemolytic and cytotoxicity testing suggest that
it is highly biocompatible. Thus, this work realizes the smart
integration of anticorrosion and antibacterial properties of biomedical
magnesium, thereby providing broader prospects for the use of magnesium.